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KMID : 1134820170460111414
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Journal of the Korean Society of Food Science and Nutrition
2017 Volume.46 No. 11 p.1414 ~ p.1418
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Degraded Products Induced by Gamma-Irradiation of Mangiferin with Anti-Diabetic Complication Effects
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Jeong Gyeong-Han
Kim Tae-Hoon
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Abstract
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Inhibition of advanced glycation end product (AGE) formation is a valuable therapeutic strategy for the regulation of diabetic complications. This study was conducted to identify potential therapeutic targets of anti-diabetic complications from irradiated mangiferin using AGE formation assay. Radiolytic degradation of the xanthone glucoside mangiferin by gamma-irradiation resulted in three degraded mangiferin analogues: mangiferdiol (1), mangiferinol (2), and isomangiferinol (3). Structures of the three newly generated compounds were characterized by interpretation of nuclear magnetic resonance (1H, 13C NMR, 1H-1H COSY, HSQC, HMBC, and NOESY) and mass spectroscopic data. The anti-diabetic complication of the generated mangiferin derivatives were tested using in vitro AGE formation method. Among the tested degraded products, mangiferinol (2) and isomangiferinol (3) exhibited significantly improved potency against AGE formation inhibitory activities with IC50 values of 5.6±0.8 and 7.6±0.9 μM, respectively. This result implies that xanthone derivatives generated from gamma-irradiated mangiferin might be beneficial for prevention of diabetic complication and related diseases.
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KEYWORD
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gamma-irradiation, mangiferin derivatives, xanthone, diabetic complication, advanced glycation end products (AGEs)
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